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Comment
. 2016 Nov 3;19(5):561-563.
doi: 10.1016/j.stem.2016.10.016.

Leukemic Stem Cells S(p)liced Off

Margarida Ferreira-Teixeira  1 , Britta Will  2
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Leukemic Stem Cells S(p)liced Off

Margarida Ferreira-Teixeira et al. Cell Stem Cell. .
Free article

Abstract

Myeloid malignancies often arise from an aging hematopoietic system and are currently incurable due to therapy-resistant, disease-reinitiating leukemic stem cells. In this issue of Cell Stem Cell, Crews et al. (2016) report RNA splice isoform signatures unique to patient-derived leukemic stem cells that constitute a therapeutic Achilles' heel of myeloid leukemia.

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