On the pharmacokinetics of cephalosporin antibiotics
- PMID: 278145
Item in Clipboard
On the pharmacokinetics of cephalosporin antibiotics
Scand J Infect Dis Suppl.
1978.
Abstract
A review is given on the pharmacokinetic characteristics of some cephalosporin antibiotics. The use of the pharmacokinetic parameters serum concentration, serum protein binding, serum half life, and apparent volume of distribution as a basis for the selection of the clinically most effective cephalosporin derivative is discussed. It is concluded that these parameters must be used in conjunction with data on tissue distribution to specialized sites, and with information on antibacterial activity and toxicity.
Similar articles
-
Pharmacokinetics of cephalosporin antibiotics.Antibiot Chemother (1971). 1978;25:123-62. doi: 10.1159/000401060. Antibiot Chemother (1971). 1978. PMID: 352251 Review. No abstract available.
-
Pharmacokinetics and clinical use of cephalosporin antibiotics.J Pharm Sci. 1975 Dec;64(12):1899-926. doi: 10.1002/jps.2600641202. J Pharm Sci. 1975. PMID: 1107514 Review. No abstract available.
-
Human serum protein binding of cephalosporin antibiotics in vitro.J Lab Clin Med. 1977 Feb;89(2):414-20. J Lab Clin Med. 1977. PMID: 833477
-
The cephalosporin antibiotics in pediatric therapy.Eur J Pediatr. 1986 Apr;144(6):532-8. doi: 10.1007/BF00496029. Eur J Pediatr. 1986. PMID: 3519228 Review.
-
Pharmacokinetics of cephalosporin antibiotics: protein-binding considerations.Chemotherapy. 1978;24(3):121-33. doi: 10.1159/000237771. Chemotherapy. 1978. PMID: 657874
Cited by
-
Comparative toxicities of cephalosporin antibiotics in a rabbit kidney cell line (LLC-RK1).Antimicrob Agents Chemother. 1988 Mar;32(3):314-8. doi: 10.1128/AAC.32.3.314. Antimicrob Agents Chemother. 1988. PMID: 3364950 Free PMC article.
-
Cefuroxime: a review of its antibacterial activity, pharmacological properties and therapeutic use.Drugs. 1979 Apr;17(4):233-66. doi: 10.2165/00003495-197917040-00001. Drugs. 1979. PMID: 37064 Review.
-
Relevance of serum protein binding of cefoxitin and cefazolin to their activities against Klebsiella pneumoniae pneumonia in rats.Antimicrob Agents Chemother. 1985 Nov;28(5):654-9. doi: 10.1128/AAC.28.5.654. Antimicrob Agents Chemother. 1985. PMID: 3911879 Free PMC article.