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Review
. 2017 Jan 1;22(1):48-65.
doi: 10.2741/4471.

MicroRNA regulation of autophagy in cardiovascular disease

Matthew A Sermersheim  1 , Ki Ho Park  1 , Kristyn Gumpper  1 , T M Ayodele Adesanya  1 , Kuncheng Song  1 , Tao Tan  1 , Xingcong Ren  2 , Jin-Ming Yang  2 , Hua Zhu  3
Affiliations
Review

MicroRNA regulation of autophagy in cardiovascular disease

Matthew A Sermersheim et al. Front Biosci (Landmark Ed). .

Abstract

Autophagy, a form of lysosomal degradation capable of eliminating dysfunctional proteins and organelles, is a cellular process associated with homeostasis. Autophagy functions in cell survival by breaking down proteins and organelles and recycling them to meet metabolic demands. However, aberrant up regulation of autophagy can function as an alternative to apoptosis. The duality of autophagy, and its regulation over cell survival/death, intimately links it with human disease. Non-coding RNAs regulate mRNA levels and elicit diverse effects on mammalian protein expression. The most studied non-coding RNAs to-date are microRNAs (miRNA). MicroRNAs function in post-transcriptional regulation, causing profound changes in protein levels, and affect many biological processes and diseases. The role and regulation of autophagy, whether it is beneficial or harmful, is a controversial topic in cardiovascular disease. A number of recent studies have identified miRNAs that target autophagy-related proteins and influence the development, progression, or treatment of cardiovascular disease. Understanding the mechanisms by which these miRNAs work can provide promising insight and potential progress towards the development of therapeutic treatments in cardiovascular disease.

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Figures

Figure 1
Figure 1
A schematic figure of key proteins that are involved in formation of the whole process of autophagy.
Figure 2
Figure 2
A schematic figure shows biogenesis of microRNAs and their functions.
Figure 3
Figure 3
Summary of identified microRNAs that target key proteins of autophagic pathway for regulation of autophagy.
See this image and copyright information in PMC

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