Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Nov 4;42(1):95.
doi: 10.1186/s13052-016-0305-0.

Atopy and autoimmune thyroid diseases: melatonin can be useful?

Gabriella D'Angelo  1 , Lucia Marseglia  2 , Sara Manti  2 , Laura Colavita  2 , Caterina Cuppari  2 , Pietro Impellizzeri  3 , Salvatore Arena  3 , Teresa Arrigo  2 , Carmelo Salpietro  2 , Eloisa Gitto  2
Affiliations
Review

Atopy and autoimmune thyroid diseases: melatonin can be useful?

Gabriella D'Angelo et al. Ital J Pediatr. .

Abstract

Recently, there has been growing interest in the relationship between allergic and autoimmune diseases. Allergy and autoimmunity can be considered two potential outcomes of dysregulated immunity and analysis of literature data shows a strong positive association between a history of Th2-mediated allergic disorders and Th1-mediated autoimmune disorders.Autoimmune thyroid diseases are the most common of all autoimmune pathological conditions.Currently, the mechanisms explaining an association among atopy, autoimmunity, and thyroid diseases are not fully understood.There are data in literature pointing to the relationship between melatonin and thyroid activity. Several studies have suggested a paracrine role for this molecule in the regulation of thyroid activity, documenting that administration, as an antioxidant, in thyroid tissues under conditions of increased oxidative stress, could be helpful to reduce the oxidative processes involved in autoimmune thyroid diseases.Although thyroid autoimmunity has been regularly associated with atopic conditions in children, the possible protective role of melatonin has not yet been investigated.This review summarizes what is known regarding the connection between atopy and autoimmune thyroid diseases, and analyses the probable beneficial action of melatonin.

Keywords: Allergic diseases; Dysregulated immune system; Melatonin; Thyroid autoimmunity.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Th1 - Th2 - Th17 response and respective cytotoxic and humoral involvement in inflammation and autoimmunity
See this image and copyright information in PMC

References

    1. Andersen YM, Egeberg A, Gislason GH, Skov L, Thyssen JP. Autoimmune diseases in adults with atopic dermatitis. J Am Acad Dermatol. 2016. - PubMed
    1. Johansson SG, Hourihane JO, Bousquet J, Bruijnzeel-Koomen C, Dreborg S, Haahtela T, Kowalski ML, Mygind N, Ring J, van Cauwenberge P, van Hage-Hamsten M, Wüthrich B, EAACI (the European Academy of Allergology and Cinical Immunology) nomenclature task force A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy. 2001;56:813–824. doi: 10.1034/j.1398-9995.2001.t01-1-00001.x. - DOI - PubMed
    1. Miraglia Del Giudice M, Maiello N, Decimo F, Fusco N, D’ Agostino B, Sullo N, Capasso M, Salpietro V, Gitto E, Ciprandi G, Marseglia GL, Perrone L. Airways allergic inflammation and L. reuterii treatment in asthmatic children. J Biol Regul Homeost Agents. 2012;26:S35–40. - PubMed
    1. Spergel JM. Epidemiology of atopic dermatitis and atopic march in children. Immunol Allergy Clin North Am. 2010;30:269–280. doi: 10.1016/j.iac.2010.06.003. - DOI - PubMed
    1. Spergel JM. From atopic dermatitis to asthma: the atopic march. Ann Allergy Asthma Immunol. 2010;105:99–106. doi: 10.1016/j.anai.2009.10.002. - DOI - PubMed