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Case Reports
. 2016 Dec;132(6):935-937.
doi: 10.1007/s00401-016-1640-3. Epub 2016 Nov 4.

Multimodal evaluation demonstrates in vivo 18F-AV-1451 uptake in autopsy-confirmed corticobasal degeneration

Corey T McMillan  1 , David J Irwin  2 , Ilya Nasrallah  3 , Jeffrey S Phillips  2 , Meredith Spindler  2 , Katya Rascovsky  2 , Kylie Ternes  2 , Charles Jester  2 , David A Wolk  2 , Linda K Kwong  4 , Virginia M-Y Lee  4 , Edward B Lee  4 , John Q Trojanowski  5 , Murray Grossman  2
Affiliations
Case Reports

Multimodal evaluation demonstrates in vivo 18F-AV-1451 uptake in autopsy-confirmed corticobasal degeneration

Corey T McMillan et al. Acta Neuropathol. 2016 Dec.
No abstract available

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Figures

Figure 1
Figure 1
Regional distribution of 18F-AV-1451 at a) baseline (15 months pre-death); b) follow-up (5 months pre-death); and c) annualized change between baseline and follow-up defined as (SUVRfollowup – SUVRbaseline) / SUVRbaseline.
Figure 2
Figure 2. MRI/DTI neuroimaging, Histopathology and 18F-AV-1451
a) Z-scores of grey matter MRI and white matter DTI relative to 100 demographically-comparable healthy controls; correlations demonstrating increased baseline (15 months pre-death) 18F-AV-1451 retention associated with reduced b) grey matter volume and c) white matter integrity; d) heatmap reflecting ordinal ratings of PHF-1 tau burden rated as severe (3+; red) in midbrain (MB), pons (PON), substantia nigra (SN), globus pallidus (GP), putamen (CP), and amygdala (AMY); moderate (2+; orange) in thalamus (THAL), medulla (M), and CA1/subiculum (HIPca) along with anterior cingulate (ACC), middle frontal (MFC), entorhinal (HIPec), angular gyrus (AGC), superior temporal (STC) cortices; mild scattered tangles (1+; yellow) in cerebellum (CB); and no pathology in primary visual cortex (PVC); e) Correlation between AT-8 percent area occupied and follow-up (5 months pre-death) 18F-AV-1451 retention.
See this image and copyright information in PMC

References

    1. Dickson DW, Kouri N, Murray ME, Josephs KA. Neuropathology of frontotemporal lobar degeneration-tau (FTLD-tau). J Mol Neurosci. 2011;45:384–389. - PMC - PubMed
    1. Johnson KA, Sperling RA, Gidicsin CM, Carmasin JS, Maye JE, Coleman RE, et al. Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer's disease dementia, mild cognitive impairment, and normal aging. Alzheimers Dement. 2013;9:S72–83. - PMC - PubMed
    1. Josephs KA, Whitwell JL, Tacik P, Duffy JR, Senjem ML, Tosakulwong N, et al. [18F]AV- 1451 tau- PET uptake does correlate with quantitatively measured 4R- tau burden in autopsy- confirmed corticobasal degeneration. Acta Neuropathol. :1–3. in press. doi: 10.1007/s00401-016-1618-1. - PMC - PubMed
    1. Lowe VJ, Curran G, Fang P, Liesinger AM, Josephs KA, Parisi JE, et al. An autoradiographic evaluation of AV-1451 Tau PET in dementia. Acta Neuropathol Commun. 2016:1–19. doi: 10.1186/s40478-016-0315-6. - PMC - PubMed
    1. Marquié M, Normandin MD, Vanderburg CR, Costantino IM, Bien EA, Rycyna LG, et al. Validating novel tau positron emission tomography tracer [F-18]-AV- 1451 (T807) on postmortem brain tissue. Ann Neurol. 2015;78:787–800. - PMC - PubMed

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