Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Apr;37(4):647-656.
doi: 10.1007/s00296-016-3593-1. Epub 2016 Nov 4.

Development of an activity disease score in patients with uveitis (UVEDAI)

Esperanza Pato  1 , Mª Auxiliadora Martin-Martinez  2 , Adela Castelló  3 , Rosalía Méndez-Fernandez  4   5 , Santiago Muñoz-Fernández  6 , Miguel Cordero-Coma  7 , Lucia Martinez-Costa  8 , Elia Valls  9 , Miguel Reyes  10 , Félix Francisco  11 , Mar Esteban  12 , Alex Fonollosa  13 , Fernando Sanchez-Alonso  2 , Cruz Fernández-Espartero  14 , Teresa Diaz-Valle  15 , José Miguel Carrasco  16 , Emma Beltran-Catalán  17 , Marisa Hernández-Garfella  18 , María Victoria Hernández  19 , Laura Pelegrin  20 , Ricardo Blanco  21 , David Diaz-Valle  4   5
Affiliations

Development of an activity disease score in patients with uveitis (UVEDAI)

Esperanza Pato et al. Rheumatol Int. 2017 Apr.

Abstract

To develop a disease activity index for patients with uveitis (UVEDAI) encompassing the relevant domains of disease activity considered important among experts in this field. The steps for designing UVEDAI were: (a) Defining the construct and establishing the domains through a formal judgment of experts, (b) A two-round Delphi study with a panel of 15 experts to determine the relevant items, (c) Selection of items: A logistic regression model was developed that set ocular inflammatory activity as the dependent variable. The construct "uveitis inflammatory activity" was defined as any intraocular inflammation that included external structures (cornea) in addition to uvea. Seven domains and 15 items were identified: best-corrected visual acuity, inflammation of the anterior chamber (anterior chamber cells, hypopyon, the presence of fibrin, active posterior keratic precipitates and iris nodules), intraocular pressure, inflammation of the vitreous cavity (vitreous haze, snowballs and snowbanks), central macular edema, inflammation of the posterior pole (the presence and number of choroidal/retinal lesions, vascular inflammation and papillitis), and global assessment from both (patient and physician). From all the variables studied in the multivariate model, anterior chamber cell grade, vitreous haze, central macular edema, inflammatory vessel sheathing, papillitis, choroidal/retinal lesions and patient evaluation were included in UVEDAI. UVEDAI is an index designed to assess the global ocular inflammatory activity in patients with uveitis. It might prove worthwhile to motorize the activity of this extraarticular manifestation of some rheumatic diseases.

Keywords: Activity index; Ocular inflammation; Outcome measures; Uveitis.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest

All authors declare that no conflicts of interest exist.

Ethical approval

This article contains a study with human participants performed by any of the authors. This study was performed following the principles outlined in the Helsinki Declaration, and the study protocol was approved by the ethics committee at all participating hospitals.

Figures

Fig. 1
Fig. 1
Probability of being classified with mild, moderate or severe uveitis according to the total score obtained
Fig. 2
Fig. 2
Receiver operating characteristic (ROC) curve and AUC for the predictive modeling accuracy to discriminate. a Patients with mild UVEITIS from patients with moderate or severe UVEITIS, b patients with mild or moderate UVEITIS from patients with severe UVEITIS
See this image and copyright information in PMC

References

    1. Yeh S, Faia LJ, Nussenblatt RB. Advances in the diagnosis and immunotherapy for ocular inflammatory disease. Semin Immunopathol. 2008;30:145–164. doi: 10.1007/s00281-008-0109-4. - DOI - PubMed
    1. Rothova A, Suttorp-van Schulten MS, Frits Treffers W, et al. Causes and frequency of blindness in patients with intraocular inflammatory disease. Br J Ophthalmol. 1996;80:332–336. doi: 10.1136/bjo.80.4.332. - DOI - PMC - PubMed
    1. Bodaghi B, Cassoux N, Wechsler B, et al. Chronic severe uveitis: etiology and visual outcome in 927 patients from a single center. Medicine (Baltimore) 2001;80:263–270. doi: 10.1097/00005792-200107000-00005. - DOI - PubMed
    1. Jabs DA, Nussenblatt RB, Rosenbaum JT, et al. Standardization of uveitis nomenclature for reporting clinical data. Results of the first international workshop. Am J Ophthalmol. 2005;140:509–516. doi: 10.1016/j.ajo.2005.03.057. - DOI - PMC - PubMed
    1. Trusko B, Thorne J, Jabs D, et al. The Standardization of Uveitis Nomenclature (SUN) Project. Development of a clinical evidence base utilizing informatics tools and techniques. Methods Inf Med. 2013;52:259–265. doi: 10.3414/ME12-01-0063. - DOI - PMC - PubMed

Publication types

LinkOut - more resources