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. 2016 Sep;470(1):368-370.
doi: 10.1134/S1607672916050197. Epub 2016 Nov 6.

Changes in morphology of actin filaments and expression of alkaline phosphatase at 3D cultivation of MG-63 osteoblast-like cells on mineralized fibroin scaffolds

A V Goncharenko  1 , N V Malyuchenko  2 , A M Moisenovich  2 , M S Kotlyarova  2 , A Yu Arkhipova  2 , A S Kon'kov  2 , I I Agapov  3 , A V Molochkov  4 , M M Moisenovich  2 , M P Kirpichnikov  2
Affiliations

Changes in morphology of actin filaments and expression of alkaline phosphatase at 3D cultivation of MG-63 osteoblast-like cells on mineralized fibroin scaffolds

A V Goncharenko et al. Dokl Biochem Biophys. 2016 Sep.

Abstract

3D cultivation of MG-63 osteoblast-like cells on mineralized fibroin scaffolds leads to an increase in the expression of alkaline phosphatase, an early marker of bone formation. Increased expression is associated with the actin cytoskeleton reorganization under the influence of 3D cultivation and osteogenic calcium phosphate component of the microcarrier.

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