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. 2016 Sep;470(1):329-331.
doi: 10.1134/S1607672916050069. Epub 2016 Nov 6.

Signaling targets of alcoholic intoxication in human skeletal muscle

T M Mirzoev  1 , Y N Lomonosova  1 , O E Zinovyeva  2 , E A Lysenko  1 , B S Shenkman  1 , T L Nemirovskaya  3   4
Affiliations

Signaling targets of alcoholic intoxication in human skeletal muscle

T M Mirzoev et al. Dokl Biochem Biophys. 2016 Sep.

Abstract

Intracellular signaling pathways were investigated in skeletal muscle cells at the early stages of alcohol addiction manifestations. No muscle fiber atrophy was observed in m. vastus lateralis of male patients. No significant changes in the signaling mechanisms that control protein degradation were detected as well. However, the concentration of the insulin-like growth factor (IGF-1) in blood plasma as well as the content of markers of intracellular signaling pathways regulating protein synthesis were significantly reduced compared to the control group.

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References

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