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. 2016 Nov;6(6):564-567.
doi: 10.1016/j.apsb.2016.05.009. Epub 2016 Jun 17.

Two new phenylpropanoid glycosides from the aerial parts of Lespedeza cuneata

Chuangfeng Zhang  1 , Jian Zhou  2 , Jingzhi Yang  1 , Chuangjun Li  1 , Jie Ma  1 , Dan Zhang  1 , Dongming Zhang  1
Affiliations

Two new phenylpropanoid glycosides from the aerial parts of Lespedeza cuneata

Chuangfeng Zhang et al. Acta Pharm Sin B. 2016 Nov.

Abstract

Two new phenylpropanoid glycosides named cuneataside E (1) and cuneataside F (2), were isolated from the aerial parts of Lespedeza cuneata (Dum. Cours.) G. Don, whose structures were E and Z isomer, respectively. Their structures were elucidated on the basis of comprehensive spectroscopic analysis (UV, IR, HR-ESI-MS, 1D and 2D NMR). In in vitro bioassays at 10 μmol/L, compound 1 showed moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HeG2 cells.

Keywords: Cuneataside E; Cuneataside F; Extraction and isolation; Hepatoprotective activity; Lespedeza cuneata; Phenylpropanoid glycosides.

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Figures

None
Graphical abstract
Figure 1
Figure 1
Structures of compounds 1 and 2.
Figure 2
Figure 2
Key HMBC (arrows, from 1H NMR to 13C NMR) correlations of compounds 1 and 2.
Figure 3
Figure 3
The NOE enhancements induced by irradiation of H-1 and H-6 for compounds 1 and 2.
See this image and copyright information in PMC

References

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