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Editorial
. 2016 Nov 1;9(11):1241-1244.
doi: 10.1242/dmm.028159.

Drug screening using model systems: some basics

Ross Cagan  1
Affiliations
Editorial

Drug screening using model systems: some basics

Ross Cagan. Dis Model Mech. .

Abstract

An increasing number of laboratories that focus on model systems are considering drug screening. Executing a drug screen is complicated enough. But the path for moving initial hits towards the clinic requires a different knowledge base and even a different mindset. In this Editorial I discuss the importance of doing some homework before you start screening. 'Lead hits', 'patentable chemical space' and 'druggability' are all concepts worth exploring when deciding which screening path to take. I discuss some of the lessons I learned that may be useful as you navigate the screening matrix.

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Conflict of interest statement

The author declares no competing or financial interests.

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