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. 2016 Oct 27:9:6641-6650.
doi: 10.2147/OTT.S116258. eCollection 2016.

Investigation of cyclin D1 rs9344 G>A polymorphism in colorectal cancer: a meta-analysis involving 13,642 subjects

Hao Qiu  1 , Chengguo Cheng  2 , Yafeng Wang  3 , Mingqiang Kang  4 , Weifeng Tang  5 , Shuchen Chen  4 , Haiyong Gu  6 , Chao Liu  7 , Yu Chen  8
Affiliations

Investigation of cyclin D1 rs9344 G>A polymorphism in colorectal cancer: a meta-analysis involving 13,642 subjects

Hao Qiu et al. Onco Targets Ther. .

Abstract

The relationship between cyclin D1 (CCND1) rs9344 G>A polymorphism and colorectal cancer (CRC) risk is still ambiguous. To obtain a precise estimation of the relationship, we performed an extensive meta-analysis based on the eligible studies. Crude odds ratios with their 95% confidence intervals were harnessed to determine the strength of correlation between CCND1 rs9344 G>A polymorphism and CRC risk under the allele, the homozygote, the dominant, and the recessive genetic models, respectively (28 studies with 5,784 CRC cases and 7,858 controls). Our results indicated evidence of the association between CCND1 rs9344 G>A polymorphism and the increased risk of CRC in four genetic models: A vs G, AA vs GG, AA+GA vs GG, and AA vs GA+GG. In a stratified analysis by cancer type of CRC, there was an increased risk of sporadic CRC found in three genetic models: A vs G, AA vs GG, and AA+GA vs GG. In a stratified analysis by ethnicity, there was an increased CRC risk found among Asians in allele comparison genetic models, as well as Caucasians in two genetic models: AA+GA vs GG and A vs T. In summary, this meta-analysis demonstrates that CCND1 rs9344 G>A polymorphism may be a risk factor for CRC.

Keywords: CCND1; colorectal cancer; meta-analysis; polymorphism; susceptibility.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Flow diagram of candidate studies selection process. Abbreviation: CCND1, cyclin D1.
Figure 2
Figure 2
Meta-analysis with a random–effects model in the different type for the association between CCND1 rs9344 G>A polymorphism and CRC risk (A vs G genetic model). Note: Weights are from random-effects analysis. Abbreviations: CI, confidence interval; CRC, colorectal cancer; HNPCC, hereditary nonpolyposis colorectal cancer; OR, odds ratio; sCRC, sporadic colorectal cancer.
Figure 3
Figure 3
Meta-analysis with a random–effects model in different races for the association between the CCND1 rs9344 G>A polymorphism and CRC risk (A vs G genetic model). Note: Weights are from random-effects analysis. Abbreviations: CI, confidence interval; CRC, colorectal cancer; OR, odds ratio.
Figure 4
Figure 4
Begg’s funnel plot of meta-analysis of the relationship between the CCND1 rs9344 G>A polymorphism and CRC risk (AA vs GA+GG genetic model). Abbreviations: CRC, colorectal cancer; OR, odds ratio; SE, standard error.
Figure 5
Figure 5
Sensitivity analysis of the influence of A vs G genetic model in overall CRC meta-analysis (random–effects estimates). Abbreviations: CI, confidence interval; CRC, colorectal cancer.
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