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Review
. 2016 Nov 25;34(10):536-545.
doi: 10.1080/07357907.2016.1245317. Epub 2016 Nov 8.

Hypoxia: A Double-Edged Sword in Cancer Therapy

Hamed Manoochehri Khoshinani  1 , Saeid Afshar  1 , Rezvan Najafi  1
Affiliations
Review

Hypoxia: A Double-Edged Sword in Cancer Therapy

Hamed Manoochehri Khoshinani et al. Cancer Invest. .

Abstract

Hypoxia is a common feature of malignant tumors. There is an interactive connection between hypoxia and chemoresistance, radioresistance, invasiveness, and angiogenesis. Therefore, tumor hypoxia has been considered as a validated target for treating cancer. This review focuses on the role of hypoxia on chemoresistance and radioresistance. In addition, we address several approaches targeting tumor hypoxia, known as hypoxia-targeted therapy.

Keywords: Chemoresistance; HIF-1; Hypoxia; Hypoxia-targeted therapy; Radioresistance.

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