Review
doi: 10.1080/07357907.2016.1245317.
Epub 2016 Nov 8.
Hypoxia: A Double-Edged Sword in Cancer Therapy
Affiliations
- PMID: 27824512
- DOI: 10.1080/07357907.2016.1245317
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Review
Hypoxia: A Double-Edged Sword in Cancer Therapy
Cancer Invest.
.
Abstract
Hypoxia is a common feature of malignant tumors. There is an interactive connection between hypoxia and chemoresistance, radioresistance, invasiveness, and angiogenesis. Therefore, tumor hypoxia has been considered as a validated target for treating cancer. This review focuses on the role of hypoxia on chemoresistance and radioresistance. In addition, we address several approaches targeting tumor hypoxia, known as hypoxia-targeted therapy.
Keywords: Chemoresistance; HIF-1; Hypoxia; Hypoxia-targeted therapy; Radioresistance.
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