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. 2016 Nov 8;11(11):e0165782.
doi: 10.1371/journal.pone.0165782. eCollection 2016.

Inflammatory Bowel Disease: How Effective Is TNF-α Suppression?

Wing-Cheong Lo  1 , Violeta Arsenescu  2 , Razvan I Arsenescu  3 , Avner Friedman  4
Affiliations

Inflammatory Bowel Disease: How Effective Is TNF-α Suppression?

Wing-Cheong Lo et al. PLoS One. .

Erratum in

Abstract

Crohn's Disease (CD) results from inappropriate response toward commensal flora. Earlier studies described CD as a Th1 mediated disease. Current models view both phenotypes as a continuum of various permutations between Th1, Th2 and Th17 pathways compounded by a range of Treg disfunctions. In the present paper, we develop a mathematical model, by a system of differential equations, which describe the dynamic relations among these T cells and their cytokines. The model identities four groups of CD patients according to up/down regulation of Th1 and Th2. The model simulations show that immunosuppression by TNF-α blockage benefits the group with Th1High/Th2Low while, by contrast, the group with Th1Low/Th2High will benefit from immune activation.

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Conflict of interest statement

Violeta Arsenescu is employed by a commercial company, Armedica LLC. The company provided support in the form of salaries for VA, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. This does not alter our adherence to PLOS ONE policies on sharing data and materials. Other authors have no competing interests.

Figures

Fig 1
Fig 1. Schematic diagram of immune system with application to inflammatory bowel disease (IBD).
Fig 2
Fig 2
Scatter plots of rank transformed T1 (A) and T2 (B) after 100 weeks versus some rank transformed parameters with statistically significant correlation (|PRCC|>0.5 and p-value <0.01). The title of each subplot shows its PRCC value.
Fig 3
Fig 3. Simulation results: fold changes of the cytokine and T cell concentrations when TNF-α is completely blocked in different types of diseases.
Blue bars represent the results of pre-treatment; red bars represent the results of post-treatment with TNF-α blockage.
See this image and copyright information in PMC

References

    1. Shim JO. Gut Microbiota in inflammatory bowel disease. Pediatr Gastroenterol Hepatol Nutr. 2013;16(1): 17–21. 10.5223/pghn.2013.16.1.17 - DOI - PMC - PubMed
    1. Mesbah-Uddin M, Elango R, Banaganapalli B, Shaik NA, Al-Abbasi FA. In-silico analysis of inflammatory bowel disease (IBD) GWAS loci to novel connections. PLoS One. 2015;10(3): e0119420 10.1371/journal.pone.0119420 - DOI - PMC - PubMed
    1. Targan SR, Shih DQ. Insights into IBD pathogenesis. Curr Gastroenterol. Rep. 2009;11(6): 473–480. - PMC - PubMed
    1. Zenewicz LA, Antov A, Flavell RA. CD4 T-cell differentiation and inflammatory bowel disease. Trends Mol Med. 2009;15(5): 199–207. 10.1016/j.molmed.2009.03.002 - DOI - PubMed
    1. Mizoguchi A, Mizoguchi E. Animal models of IBD: linkage to human disease. Curr Opin Pharmacol. 2010;10(5): 578–87. 10.1016/j.coph.2010.05.007 - DOI - PMC - PubMed

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