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Meta-Analysis
. 2016 Nov 8;11(11):e0165861.
doi: 10.1371/journal.pone.0165861. eCollection 2016.

Meta-Analysis of the Association between Tea Intake and the Risk of Cognitive Disorders

Qing-Ping Ma  1 , Chen Huang  1 , Qiao-Yun Cui  1 , Ding-Jun Yang  1 , Kang Sun  1 , Xuan Chen  1 , Xing-Hui Li  1
Affiliations
Meta-Analysis

Meta-Analysis of the Association between Tea Intake and the Risk of Cognitive Disorders

Qing-Ping Ma et al. PLoS One. .

Abstract

Background: Alzheimer's disease is a common neurodegenerative disorder in elderly. This study was aimed to systematically evaluate the association between tea intake and the risk of cognitive disorders by meta-analysis.

Methods and findings: PubMed, Embase and Wanfang databases were systematically searched and a total of 26 observational studies were included in this study. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were calculated and pooled by using fixed or random effects models according to the degree of heterogeneity.

Results: The overall pooled analysis indicated that tea intake could significantly reduce the risk of cognitive disorders (OR = 0.65, 95%CI = 0.58-0.73). Subgroup analyses were conducted based on study design, population, frequency of tea drinking and type of cognitive disorders. The results showed that tea drinking was significantly associated with the reduced incidence of cognitive disorders in all of subgroups based on study design and frequency of tea drinking. In particular, tea drinking was inversely associated with the risk of cognitive impairment (CoI), mild cognitive impairment (MCI), cognitive decline and ungrouped cognitive disorders. Moreover, for population subgroups, the significant association was only found in Chinese people.

Conclusion: Our study suggests that daily tea drinking is associated with decreased risk of CoI, MCI and cognitive decline in the elderly. However, the association between tea intake and Alzheimer's disease remains elusive.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Study selection process for this meta-analysis.
Fig 2
Fig 2. Overall pooled analysis of association between tea intake and the cognitive disorders.
Fig 3
Fig 3. Subgroup analysis of association between tea intake and the cognitive disorders based on study design.
Fig 4
Fig 4. Subgroup analysis of association between tea intake and the cognitive disorders based on population.
Fig 5
Fig 5. Subgroup analysis of association between tea intake and the cognitive disorders based on tea drinking frequency.
Ungrouped means studies without information on drinking frequency.
Fig 6
Fig 6. Subgroup analysis of association between tea intake and the cognitive disorders based on type of cognitive disorders.
Fig 7
Fig 7. Funnel plot for assessment of publication bias.
See this image and copyright information in PMC

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