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Published Erratum
. 2016 Dec:499:397-398.
doi: 10.1016/j.virol.2016.10.018.

Corrigendum to 'Phagocytic cells contribute to the antibody-mediated elimination of pulmonary-infected SARS coronavirus' [Virology (2014) 157-168]

Fumihiko Yasui  1 , Michinori Kohara  2 , Masahiro Kitabatake  3 , Tetsu Nishiwaki  4 , Hideki Fujii  5 , Chise Tateno  6 , Misako Yoneda  7 , Kouichi Morita  8 , Kouji Matsushima  4 , Shigeo Koyasu  9 , Chieko Kai  7
Affiliations
Published Erratum

Corrigendum to 'Phagocytic cells contribute to the antibody-mediated elimination of pulmonary-infected SARS coronavirus' [Virology (2014) 157-168]

Fumihiko Yasui et al. Virology. 2016 Dec.
No abstract available

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Figures

Fig. 1
Fig. 1
CD4+ T cells play an important role in the control of SARS-CoV infection. (A–C) aged BALB/c mice (n=4–7/time point), young BALB/c mice (n=5–10/time point), and young SCID mice (n=4–8/time point) were infected intranasally with 1×105 TCID50 of SARS-CoV Vietnam strain. (A) Virus titers in the lung (TCID50/g lung tissue) of aged BALB/c mice (closed circles), young BALB/c mice (gray circles), or young SCID mice (open squares) sacrificed at 2, 4, 6, 9, or 21 dpi (except for 20 dpi in young BALB/c mice). ⁎p<0.05, ⁎⁎p<0.01 (compared with young BALB/c mice and SCID mice at the respective time point). N.D.: not detected. (B) Representative lung sections (hematoxylin and eosin staining; section thickness 4 μm) from aged BALB/c mice at 9 dpi (a and c) and 21 dpi (b and d) and from young SCID mice at 9 dpi (e and g) and 21 dpi (f and h). For all micrographs, original magnification is 200×. (C) Detection of virus-infected cells in the lungs at 2, 9, or 21 dpi (SARS-CoV nucleocapsid protein [brown staining]; original magnification, 400×). (D) Temporal change of pulmonary virus titer in the following: aged BALB/c mice (green); untreated SCID mice (blue); SCID mice transplanted with splenocytes from naïve BALB/c mice (yellow); or SCID mice transplanted with splenocytes from sensitized BALB/c mice (red). Splenocytes (4×107 cells) were administered intravenously to each recipient SCID mouse 1 day before infection. Data are presented as mean±S.D. (n=4/time point). ⁎p<0.05 (compared with naïve splenocyte-transplanted SCID mice at 2 dpi or with other groups at 4 dpi). (E) Representative lung sections (hematoxylin and eosin staining; section thickness 4 μm) from each group in (D) at 9 dpi. SPL, splenocyte. For all micrographs, original magnification is 200×. (F) Flow cytometry analysis of CD4 and CD8 expression on lymphocytes isolated from spleen 1 day after administration of the indicated mAb. (G) Virus titers in the lung of untreated (white), CD8+ cell-depleted (light gray), CD4+ cell-depleted (dark gray), or CD4+ and CD8+ cell-depleted BALB/c mice (black) at 6 and 9 dpi. The limit of detection was <1×103 TCID50/g lung. Data are presented as mean±S.D. (n=3–7/time point).
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