Serum HBV pgRNA as a clinical marker for cccDNA activity

Affiliations

¹ I. Dept. of Internal Medicine, Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
² I. Dept. of Internal Medicine, Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel site, Germany. Electronic address: m.dandri@uke.de.
³ I. Dept. of Internal Medicine, Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute of Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address: mluetgeh@uke.de.

Comment

Katja Giersch et al. J Hepatol. 2017 Feb.

. 2017 Feb;66(2):460-462.

doi: 10.1016/j.jhep.2016.09.028. Epub 2016 Nov 5.

¹ I. Dept. of Internal Medicine, Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
² I. Dept. of Internal Medicine, Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel site, Germany. Electronic address: m.dandri@uke.de.
³ I. Dept. of Internal Medicine, Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute of Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address: mluetgeh@uke.de.

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Reply to: "Serum HBV pgRNA as a clinical marker for cccDNA activity": Consistent loss of serum HBV RNA might predict the "para-functional cure" of chronic hepatitis B.
Wang J, Du M, Huang H, Chen R, Niu J, Jiang J, Zhuang H, Lu F. Wang J, et al. J Hepatol. 2017 Feb;66(2):462-463. doi: 10.1016/j.jhep.2016.10.034. Epub 2016 Nov 5. J Hepatol. 2017. PMID: 27826054 No abstract available.

Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound.
Wang J, Shen T, Huang X, Kumar GR, Chen X, Zeng Z, Zhang R, Chen R, Li T, Zhang T, Yuan Q, Li PC, Huang Q, Colonno R, Jia J, Hou J, McCrae MA, Gao Z, Ren H, Xia N, Zhuang H, Lu F. Wang J, et al. J Hepatol. 2016 Oct;65(4):700-710. doi: 10.1016/j.jhep.2016.05.029. Epub 2016 May 28. J Hepatol. 2016. PMID: 27245431