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Editorial
. 2016 Oct;5(5):438-443.
doi: 10.21037/hbsn.2016.09.11.

Inflammation, mitochondrial metabolism and nutrition: the multi-faceted progression of non-alcoholic fatty liver disease to hepatocellular carcinoma

Noemí Cabré  1 , Jordi Camps  1 , Jorge Joven  2
Affiliations
Editorial

Inflammation, mitochondrial metabolism and nutrition: the multi-faceted progression of non-alcoholic fatty liver disease to hepatocellular carcinoma

Noemí Cabré et al. Hepatobiliary Surg Nutr. 2016 Oct.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Bariatric surgery restores hepatic histologic features of NAFLD. Representative micrographs illustrating the expected histologic changes in the liver of morbidly obese patients 1 year after successful bariatric surgery. In most patients, steatosis (A,D) and NASH (B,E) are reverted and fibrosis (C,F) is significantly improved. NAFLD, non-alcoholic fat liver disease.
Figure 2
Figure 2
The role of one-carbon metabolism in NAFLD and beyond. The pathways for the metabolism of essential micronutrients affecting the development of NAFLD and HCC intersect at the formation of methionine from homocysteine. Of note, the flux of dietary amino acids, B vitamins and THF may vary during selective deficiencies. The attractive hypothesis linking nutritional therapies and NAFLD progression requires reliable clinical data in the future. 5-mTHF, 5-methylenetetrahydrofolate; SAH, S-adenosylhomocysteine; SAM, S-adenosylmethionine; THF, tetrahydrofolate; NAFLD, non-alcoholic fat liver disease.
See this image and copyright information in PMC

Comment on

  • NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis.
    Ma C, Kesarwala AH, Eggert T, Medina-Echeverz J, Kleiner DE, Jin P, Stroncek DF, Terabe M, Kapoor V, ElGindi M, Han M, Thornton AM, Zhang H, Egger M, Luo J, Felsher DW, McVicar DW, Weber A, Heikenwalder M, Greten TF. Ma C, et al. Nature. 2016 Mar 10;531(7593):253-7. doi: 10.1038/nature16969. Epub 2016 Mar 2. Nature. 2016. PMID: 26934227 Free PMC article.

References

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    1. Ma C, Kesarwala AH, Eggert T, et al. NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis. Nature 2016;531:253-7. 10.1038/nature16969 - DOI - PMC - PubMed

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