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Clinical Trial
. 2016 Sep-Oct;91(5):580-583.
doi: 10.1590/abd1806-4841.20164655.

C-reactive protein serum level in patients with psoriasis before and after treatment with narrow-band ultraviolet B

Mahmoud Farshchian  1 , Akram Ansar  1 , Mohammadreza Sobhan  1 , Valiollah Hoseinpoor  1
Affiliations
Clinical Trial

C-reactive protein serum level in patients with psoriasis before and after treatment with narrow-band ultraviolet B

Mahmoud Farshchian et al. An Bras Dermatol. 2016 Sep-Oct.

Abstract

Background:: C-reactive protein is an inflammatory biomarker and its level increases in the serum of psoriatic patients. Its level is also associated with Psoriasis Area and Severity Index score.

Objective:: The aim of this study was to assess the decrement of serum C-reactive protein level with narrow-band ultraviolet B (NB-UVB) therapy.

Methods:: C-reactive protein serum levels in psoriasis patients were measured before and after treatment with NB-UVB and the data were analyzed in relation to the Psoriasis Area and Severity Index score improvement.

Results:: Baseline C-reactive protein levels among psoriatic patients were higher than normal. These levels decreased significantly after treatment (P<0.001). At the beginning of the study, patients with higher levels of C-reactive protein also had more extensive and severe skin involvement. The highest decrease in C-reactive protein was observed in patients who responded better to the treatment and achieved a higher Psoriasis Area and Severity Index 75%. There was an association between baseline Psoriasis Area and Severity Index scores and C-reactive protein levels.

Conclusion:: Patients with moderate to severe plaque-type psoriasis had active systemic inflammation, which was demonstrated by increased levels of C-reactive protein. Furthermore, skin disease severity was correlated with C-reactive protein levels. Phototherapy healed the psoriatic skin lesions and reduced inflammation, while decreasing C-reactive protein levels.

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Conflict of interest statement

None

Figures

Graph 1
Graph 1
Comparison of CRP serum levels in 25 patients before and after treatment by NB-UVB
Graph 2
Graph 2
Comparison of PASI scores in 25 patients before and after treatment using NB-UVB
Graph 3
Graph 3
The relationship between CRP serum levels in 25 patients, pre- and post-treatment using NBUVB and PASI 75%
See this image and copyright information in PMC

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