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Comment
. 2016 Nov 8;24(5):649-650.
doi: 10.1016/j.cmet.2016.10.015.

Lactate Wreaks Havoc on Tumor-Infiltrating T and NK Cells

Kristen E N Scott  1 , John L Cleveland  2
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Comment

Lactate Wreaks Havoc on Tumor-Infiltrating T and NK Cells

Kristen E N Scott et al. Cell Metab. .
Free article

Abstract

Both cancer cells and activated T and NK immune cells display enhanced nutrient uptake and metabolism characteristic of the Warburg phenotype. In this issue of Cell Metabolism, Brand et al. (2016) demonstrate that cancer cell LDHA-derived lactic acid selectively disables T and NK cell activation and tumor immune surveillance.

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  • LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.
    Brand A, Singer K, Koehl GE, Kolitzus M, Schoenhammer G, Thiel A, Matos C, Bruss C, Klobuch S, Peter K, Kastenberger M, Bogdan C, Schleicher U, Mackensen A, Ullrich E, Fichtner-Feigl S, Kesselring R, Mack M, Ritter U, Schmid M, Blank C, Dettmer K, Oefner PJ, Hoffmann P, Walenta S, Geissler EK, Pouyssegur J, Villunger A, Steven A, Seliger B, Schreml S, Haferkamp S, Kohl E, Karrer S, Berneburg M, Herr W, Mueller-Klieser W, Renner K, Kreutz M. Brand A, et al. Cell Metab. 2016 Nov 8;24(5):657-671. doi: 10.1016/j.cmet.2016.08.011. Epub 2016 Sep 15. Cell Metab. 2016. PMID: 27641098

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