Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2016 Nov 8;24(5):653-654.
doi: 10.1016/j.cmet.2016.10.016.

Macrophage Metabolism Shapes Angiogenesis in Tumors

Alberto Mantovani  1 , Massimo Locati  2
Affiliations
Free article
Comment

Macrophage Metabolism Shapes Angiogenesis in Tumors

Alberto Mantovani et al. Cell Metab. .
Free article

Erratum in

Abstract

In this issue, Wenes et al. (2016) show that REDD1, an mTOR inhibitor induced by hypoxia, enhances glycolysis in tumor-associated macrophages (TAMs). Metabolic competition for glucose between TAMs and endothelial cells leads to an abnormal, leaky vascular network. Targeting REDD1 normalizes glycolysis in TAMs, stabilizes the vascular network, and inhibits metastasis.

PubMed Disclaimer

Comment on

LinkOut - more resources