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Editorial
. 2016 Dec 27;7(52):85678-85679.
doi: 10.18632/oncotarget.13144.

Assembly of early machinery for autophagy induction: novel insights from high resolution microscopy

Nicholas T Ktistakis, Simon A Walker, Eleftherios Karanasios
Editorial

Assembly of early machinery for autophagy induction: novel insights from high resolution microscopy

Nicholas T Ktistakis et al. Oncotarget. .
No abstract available

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Figures

Figure 1
Figure 1. A speculative model of early autophagy steps
Nucleation. A tubular extension of the ER together with a small number of ATG9 vesicles provide a platform for the assembly of ULK1 particles in an ordered arrangement. Such an arrangement is evident in dSTORM images of ER and ATG13, a component of the ULK1 complex (images to the right). The next step during nucleation involves formation of PI3P tubular extensions surrounding the ULK1 assembly. These extensions have been drawn to originate from the apposing ER to fit the model in Uemura et al. (model on bottom right reproduced with permission from [6]; omegasome-related tubules are depicted in green). Elongation. Continuous PI3P synthesis, LC3 lipidation and additional membrane supply (perhaps via ER derived vesicles amongst others) expands the site.
See this image and copyright information in PMC

Comment on

  • Commentary on: Dynamic association of the ULK1 complex with omegasomes during autophagy induction by Karanasios, J Cell Sci. 2013; 126:5224-38. doi: 10.1242/jcs.132415.

References

    1. Mizushima N, Komatsu M. Cell. 2011;147:728–741. - PubMed
    1. Hamasaki M, et al. Nature. 2013;495:389–93. - PubMed
    1. Karanasios E, et al. J Cell Sci. 2013;126:5224–38. - PubMed
    1. Hayashi-Nishino M, et al. Nat Cell Biol. 2009;11:1433–7. - PubMed
    1. Yla-Attila P, et al. Autophagy. 2009;5:1180–5. - PubMed

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