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Review
. 2016 Oct;8(Suppl 1):S39-S41.
doi: 10.4103/0975-7406.191964.

Bone morphogenetic proteins: Signaling periodontal bone regeneration and repair

G Sai Anusuya  1 , M Kandasamy  2 , S A Jacob Raja  1 , S Sabarinathan  3 , P Ravishankar  4 , Balu Kandhasamy  5
Affiliations
Review

Bone morphogenetic proteins: Signaling periodontal bone regeneration and repair

G Sai Anusuya et al. J Pharm Bioallied Sci. 2016 Oct.

Abstract

Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. Originally discovered by their ability to induce the formation of bone and cartilage, BMPs are now considered to constitute a group of pivotal morphogenetic signals, orchestrating tissue architecture throughout the body. The important functioning of BMP signals in physiology is emphasized by the multitude of roles for dysregulated BMP signaling in pathological processes. A study done wherein it was found that protein extracts from bone implanted into the animals at nonbone sites induced the formation of new cartilage and bone tissue. This protein extract contained multiple factors that stimulated bone formation and was termed as "BMP." There are at least 15 different BMPs identified to date and are a part of the transforming growth factor-β super family. The most widely studied BMPs are BMP-2, BMP-3 (osteogenin), BMP-4, and BMP-7 (osteogenic protein-1). Now, any recombination type of morphogenic proteins have been synthesized, for example - recombinant human BMPs.

Keywords: Bone morphogenetic proteins; cytokines; growth factor; periodontal regeneration.

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References

    1. McCauly L, Somerman M. Biologic modifiers in periodontal regeneration. Dent Clin North Am. 1998;42(2):361–87. - PubMed
    1. Sporn MB, Todaro GJ. Autocrine secretion and malignant transformation of cells. N Engl J Med. 1980;303:878–80. - PubMed
    1. McGeachie J, Tennant M. Growth factors and their implications for clinicians: A brief review. Aust Dent J. 1997;42:375–80. - PubMed
    1. McKay I, Leigh I. Growth Factors: A Practical Approach. Oxford: Oxford University Press; 1993.
    1. Slack JM, Darlington BG, Heath JK, Godsave SF. Mesoderm induction in early Xenopus embryos by heparin-binding growth factors. Nature. 1987;326:197–200. - PubMed