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. 2016 Oct;8(Suppl 1):S126-S132.
doi: 10.4103/0975-7406.191941.

Comparative evaluation of serum and salivary immunoglobulin G and A levels with total serum protein in oral submucous fibrosis patients: A case control study

M Kandasamy  1 , N Jaisanghar  2 , Ravi David Austin  3 , Kumar Chandan Srivastava  4 , G Sai Anusuya  5 , N Anisa  6
Affiliations

Comparative evaluation of serum and salivary immunoglobulin G and A levels with total serum protein in oral submucous fibrosis patients: A case control study

M Kandasamy et al. J Pharm Bioallied Sci. 2016 Oct.

Abstract

Aim and objective: The objective of this study is to estimate and compare the serum and salivary immunoglobulin G and A (IgG, IgA) levels in various stages of oral submucous fibrosis (OSMF) patients and relate it to total serum protein (TSP) and hemoglobin (Hb) levels.

Materials and methods: The sample for the present study comprised a total of 20 healthy controls, 20 OSMF patients. About 5 ml of blood and 2 ml of saliva were collected. Quantitative analysis of serum and salivary IgG, IgA was done by turbidometric immunoassay. TSP and Hb were estimated by Biuret and cyanmethemoglobin methods, respectively.

Results: Serum and salivary IgA and IgG levels were statistically significantly increased (P < 0.001) in OSMF patients when compared to controls. Also serum and salivary IgG and IgA levels showed significantly increased (P < 0.01) in all the three staging of OSMF when compared to control group. Hb levels and TSP levels were significantly decreased (P < 0.001) in OSMF patients when compared to controls. One-way ANOVA, Pearson's correlation, and unpaired t-test were used for statistical analysis.

Conclusion: The elevated levels of IgG and IgA are also in favor of polygammapathy, which are nonspecific and nondiagnostic objective reflections of an underlying disease. Decreased TSP is a result of host response and Hb, acts as an indicator of nutritional status plays an important role. It is also observed from the present study that the severity of OSMF was directly proportional to the estimated elevated levels of the major IgG and IgA. A need is also felt for the knowledge of immunoprofile estimation in etiology and pathogenesis that would prove a great asset in the proper assessment of this condition.

Keywords: Hemoglobin; immunoglobulin A; immunoglobulin G; oral squamous cell carcinoma; oral submucous fibrosis; total serum protein.

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References

    1. Murti PR, Bhonsle RB, Gupta PC, Daftary DK, Pindborg JJ, Mehta FS. Etiology of oral submucous fibrosis with special reference to the role of areca nut chewing. J Oral Pathol Med. 1995;24:145–52. - PubMed
    1. Pindborg JJ, Sirsat SM. Oral submucous fibrosis. Oral Surg Oral Med Oral Pathol. 1966;22:764–79. - PubMed
    1. Rajendran R. Oral submucous fibrosis: Etiology, pathogenesis, and future research. Bull World Health Organ. 1994;72:985–96. - PMC - PubMed
    1. Tilakaratne WM, Klinikowski MF, Saku T, Peters TJ, Warnakulasuriya S. Oral submucous fibrosis: Review on etiology and pathogenesis. Oral Oncol. 2006;42:561–8. - PubMed
    1. Dyavanagoudar SN. Oral sub mucous fibrosis: Review of etiopathogenesis. J Cancer Sci Ther. 2009;1:72–7.