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Case Reports
. 2016 Dec;9(4):169-170.
doi: 10.1177/1753495X16655021. Epub 2016 Aug 3.

Glanzmann thrombasthenia in pregnancy: Optimising maternal and fetal outcomes

A Wijemanne  1 , I Watt-Coote  1 , S Austin  2
Affiliations
Case Reports

Glanzmann thrombasthenia in pregnancy: Optimising maternal and fetal outcomes

A Wijemanne et al. Obstet Med. 2016 Dec.

Abstract

Glanzmann thrombasthenia is a rare autosomal recessive haemorrhagic disorder. The risks of miscarriage, antepartum and postpartum haemorrhage, and neonatal complications are all increased in individuals presenting with the disease in pregnancy. Some individuals may develop antibodies to platelet glycoproteins; the presence of these antibodies is a rare cause of neonatal alloimmune thrombocytopenia and potential intracranial haemorrhage. Multidisciplinary care is paramount for ensuring optimal fetal and maternal outcomes in such cases. We report a case of neonatal alloimmune thrombocytopenia secondary to maternal Glanzmann thrombasthenia in pregnancy.

Keywords: Glanzmann thrombasthenia; High-risk pregnancy; haematology; haemorrhage; maternal-fetal medicine; neonatal alloimmune thrombocytopenia.

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