Glanzmann thrombasthenia in pregnancy: Optimising maternal and fetal outcomes
- PMID: 27829878
- PMCID: PMC5089344
- DOI: 10.1177/1753495X16655021
Glanzmann thrombasthenia in pregnancy: Optimising maternal and fetal outcomes
Abstract
Glanzmann thrombasthenia is a rare autosomal recessive haemorrhagic disorder. The risks of miscarriage, antepartum and postpartum haemorrhage, and neonatal complications are all increased in individuals presenting with the disease in pregnancy. Some individuals may develop antibodies to platelet glycoproteins; the presence of these antibodies is a rare cause of neonatal alloimmune thrombocytopenia and potential intracranial haemorrhage. Multidisciplinary care is paramount for ensuring optimal fetal and maternal outcomes in such cases. We report a case of neonatal alloimmune thrombocytopenia secondary to maternal Glanzmann thrombasthenia in pregnancy.
Keywords: Glanzmann thrombasthenia; High-risk pregnancy; haematology; haemorrhage; maternal-fetal medicine; neonatal alloimmune thrombocytopenia.
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