Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016:2016:1425147.
doi: 10.1155/2016/1425147. Epub 2016 Oct 17.

The Seroprevalence of Human Cystic Echinococcosis in Iran: A Systematic Review and Meta-Analysis Study

Reza Shafiei  1 , Saeed Hosseini Teshnizi  2 , Kurosh Kalantar  3 , Maryam Gholami  1 , Golnush Mirzaee  4 , Fatemeh Mirzaee  5
Affiliations
Review

The Seroprevalence of Human Cystic Echinococcosis in Iran: A Systematic Review and Meta-Analysis Study

Reza Shafiei et al. J Parasitol Res. 2016.

Abstract

Human cystic echinococcosis (HCE), a zoonotic infection of the larval stage of Echinococcus granulosus, has high effect on public health in human population all around the world. Iran is one of the most important endemic areas in the Middle East. This systematic review and meta-analysis was performed to evaluate the seroprevalence of HCE in Iranian population. An electronic search for articles from 1985 until April 2015 was performed using data bases PubMed, Scopus, Google Scholar, Magiran, IranMedex, Iran Doc, and Scientific Information Database (SID) both in English and in Persian. A random-effects meta-analysis was used to combine results from individual studies. The information was analyzed by STATA version 11.1. A total of 33 articles met our eligibility criteria and were included in a meta-analysis. The pooled estimate of the prevalence of HCE based on random-effects model was estimated 6.0% (95% CI: 4.0%, 7.0%). The prevalence of the disease significantly increased with age and prevalence rate in males was significantly lower than females (p < 0.001). The using of CIE or CCIEP method was also significantly greater than the other methods (p < 0.001). There was a publication bias in prevalence of studies. HCE is highly prevalent in Iran. Public education for preventive strategies and finally reducing transmission of the parasite and infection in population is needed.

PubMed Disclaimer

Figures

Figure 1
Figure 1
PRISMA flowchart describing the study design process.
Figure 2
Figure 2
Graphic representation of prevalence (%) of HCE in provinces in Iran. The asterisk (∗) means the minimum and maximum of prevalence in province.
Figure 3
Figure 3
Forest plot of meta-analysis results for prevalence of CE. The middle point of each line indicates the prevalence rate and the length of line indicates 95% confidence interval of each study. Rhombus shape indicates 95% confidence interval for all studies.
See this image and copyright information in PMC

References

    1. Pawlowski Z., Vuitton D. Echinococcosis in humans: clinical aspects, diagnpsis and treatment. In: Eckert J., Gemmel M. A., Meslin F.-X., Pawłowski Z. S., editors. WHO/OIE Manual on Echinococcosis in Humans and Animals: A Public Health Problem of Global Concern. Paris, France: World Health Organization and World Organization for Animal Health; 2001. pp. 20–66.
    1. Zhang W., Wen H., Li J., Lin R., McManus D. P. Immunology and immunodiagnosis of cystic echinococcosis: an update. Clinical and Developmental Immunology. 2012;2012:10. doi: 10.1155/2012/101895.101895 - DOI - PMC - PubMed
    1. Fasihi Harandi M., Budke C. M., Rostami S. The monetary burden of cystic echinococcosis in Iran. PLoS Neglected Tropical Diseases. 2012;6(11) doi: 10.1371/journal.pntd.0001915.e1915 - DOI - PMC - PubMed
    1. Torgerson P. R., Deplazes P. Echinococcosis: diagnosis and diagnostic interpretation in population studies. Trends in Parasitology. 2009;25(4):164–170. doi: 10.1016/j.pt.2008.12.008. - DOI - PubMed
    1. Moro P., Schantz P. M. Echinococcosis: a review. International Journal of Infectious Diseases. 2009;13(2):125–133. doi: 10.1016/j.ijid.2008.03.037. - DOI - PubMed

LinkOut - more resources