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Clinical Trial
. 1989;108(5):308-13.
doi: 10.1007/BF00932321.

Flucloxacillin compared with cefazolin in short-term prophylaxis for clean orthopedic surgery

J Van Meirhaeghe  1 , R Verdonk, G Verschraegen, P Myny, G Paeme, H Claessens
Affiliations
Clinical Trial

Flucloxacillin compared with cefazolin in short-term prophylaxis for clean orthopedic surgery

J Van Meirhaeghe et al. Arch Orthop Trauma Surg. 1989.

Abstract

Two-hundred and fifty-two patients were included in a prospective, randomized, double-blind trial comparing the efficacy of flucloxacillin with that of cefazolin for clean orthopedic surgery. The preventive antibiotic regimen consisted of three 1-g injections perioperatively. There were 126 patients in each group, and the follow-up period was at least 6 months. Two deep (1.6%) and five superficial (4.0%) infections occurred in the flucloxacillin group. Three deep (2.4%) and five superficial (4.0%) infections developed in the cefazolin group.

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