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Editorial
. 2017 Jan;62(1):4-6.
doi: 10.1007/s10620-016-4328-6.

Intestinal Ischemia-Reperfusion: Rooting for the SOCS?

Younggeon Jin  1 , Anthony T Blikslager  2
Affiliations
Editorial

Intestinal Ischemia-Reperfusion: Rooting for the SOCS?

Younggeon Jin et al. Dig Dis Sci. 2017 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Schematic of the signaling pathways studied by Liu et al., in which IR injury activates TLR-4 through exposure to luminal bacterial toxins such as lipopolysaccharide (LPS) in damaged intestine. TRAF6 activation results in downstream inflammatory responses typical of sepsis. In ischemic preconditioning, SOCS-1 is upregulated and thought to suppress TLR4 signaling, thereby having the potential to downregulate pro-inflammatory pathways in patients at risk of IR injury.
See this image and copyright information in PMC

Comment on

References

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