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. 1989 Sep 15;163(2):1107-12.
doi: 10.1016/0006-291x(89)92335-8.

Increased level of apolipoprotein B mRNA in the liver of ventromedial hypothalamus lesioned obese rats

Y Inui  1 , S Kawata, Y Matsuzawa, K Tokunaga, S Fujioka, S Tamura, T Kobatake, Y Keno, S Tarui
Affiliations

Increased level of apolipoprotein B mRNA in the liver of ventromedial hypothalamus lesioned obese rats

Y Inui et al. Biochem Biophys Res Commun. .

Abstract

The mRNA level of apolipoprotein B (apoB), which is a principal protein component of nascent very low density lipoprotein (VLDL), was determined in parallel with the measurement of acetyl-coenzyme A (Ac-CoA) carboxylase activity in the liver of ventromedial hypothalamus (VMH) lesioned obese rats. Eight weeks after the electrolysis of the bilateral VMH, the level of apoB mRNA in the VMH-lesioned rats was about 1.5-fold higher than that in the sham-operated rats, indicating increased apoB synthesis in the liver of the VMH-lesioned obese rats. The activity of Ac-CoA carboxylase, which is a rate-limiting enzyme for the fatty acid biosynthesis, was about 1.8-fold higher in the VMH-lesioned rats. These observations indicated that VLDL synthesis is increased in the liver of VMH-lesioned obese rats.

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