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. 1989 Sep 29;163(3):1243-7.
doi: 10.1016/0006-291x(89)91111-x.

Identification of an allatostatin from adult Diploptera punctata

G E Pratt  1 , D E Farnsworth, N R Siegel, K F Fok, R Feyereisen
Affiliations

Identification of an allatostatin from adult Diploptera punctata

G E Pratt et al. Biochem Biophys Res Commun. .

Abstract

A peptide (allatostatin) causing strong and rapid inhibition of juvenile hormone synthesis in vitro by corpora allata from reproductively active females has been isolated from brain/retrocerebral complexes of the cockroach Diploptera punctata. The primary structure of this 13-residue peptide has been determined: Ala-Pro-Ser-Gly-Ala-Gln-Arg-Leu-Tyr-Gly-Phe-Gly-Leu-NH2. Removal of the terminal amide group caused at least a ten thousandfold loss of activity. This neurohormone has no sequence similarity with any other known neuropeptide. Its target in the biosynthetic pathway is located prior to the conversion of farnesol to juvenile hormone.

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