TH9 cells in anti-tumor immunity

Abstract

IL-9 was initially identified as a T cell growth factor with a potential oncogenic activity. Accordingly, IL-9 drives tumor growth in most hematological cancers. However, the links between IL-9 and cancer progression have been recently revisited following the discovery of T_H9 cells. T_H9 cells, which have been characterized in 2008 as a proinflammatory CD4 T cell subset that promotes protection against parasites and drives tissue inflammation in colitis, actually harbor potent IL-9-dependent anti-cancer properties in solid tumors and especially melanoma. While the molecular mechanisms underlying these observations are still being investigated, T_H9 cells were demonstrated to activate both innate and adaptive immune responses, thereby favoring anti-cancer immunity and tumor elimination. Human T_H9 cells have also been identified in cancer tissues, but their functions remain elusive. The present review aims to discuss the anti-cancer potential of T_H9 cells and their possible clinical relevance for cancer immunotherapy.

Keywords: Adaptive immunity; CD4 T cells; Cancer; Gene transcription; Immunomodulation; Innate immunity.

Fig. 1

Pleiotropic effects of T_H9 cells in anti-tumor immunity

Fig. 2

Signaling pathways that promote interleukin-9 and interleukin-21 production