Radiation-induced lichen sclerosus of the vulva : First report in the medical literature

Lisa R Edwards¹, Emily D Privette², James W Patterson^{2

3}, Georgi Tchernev⁴, Anastasiya Atanasova Chokoeva^{5

6}, Uwe Wollina⁷, Torello Lotti⁸, Barbara B Wilson²

Affiliations

¹ School of Medicine, University of Virginia Health System, Charlottesville, VA, USA.
² Department of Dermatology, University of Virginia Health System, Charlottesville, VA, USA.
³ Department of Pathology, University of Virginia Health System, 1215 Lee Street, Box 800214, 22908, Charlottesville, VA, USA.
⁴ Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR), General Skobelev blvd. 79, 1606, Sofia, Bulgaria. georgi_tchernev@yahoo.de.
⁵ "Onkoderma"-Policlinic for Dermatology and Dermatologic Surgery, General Skobelev 26 blvd., Sofia, Bulgaria.
⁶ Department of Dermatology and Venereology, Medical University of Plovdiv, Plovdiv, Bulgaria.
⁷ Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Friedrichstrasse 41, 01067, Dresden, Germany.
⁸ Dermatology, University of Rome "G.Marconi", Rome, Italy.

PMID: 27832422
DOI: 10.1007/s10354-016-0525-3

Case Reports

Radiation-induced lichen sclerosus of the vulva : First report in the medical literature

Lisa R Edwards et al. Wien Med Wochenschr. 2017 Mar.

. 2017 Mar;167(3-4):74-77.

doi: 10.1007/s10354-016-0525-3. Epub 2016 Nov 10.

Authors

Lisa R Edwards¹, Emily D Privette², James W Patterson^{2

3}, Georgi Tchernev⁴, Anastasiya Atanasova Chokoeva^{5

6}, Uwe Wollina⁷, Torello Lotti⁸, Barbara B Wilson²

Affiliations

¹ School of Medicine, University of Virginia Health System, Charlottesville, VA, USA.
² Department of Dermatology, University of Virginia Health System, Charlottesville, VA, USA.
³ Department of Pathology, University of Virginia Health System, 1215 Lee Street, Box 800214, 22908, Charlottesville, VA, USA.
⁴ Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR), General Skobelev blvd. 79, 1606, Sofia, Bulgaria. georgi_tchernev@yahoo.de.
⁵ "Onkoderma"-Policlinic for Dermatology and Dermatologic Surgery, General Skobelev 26 blvd., Sofia, Bulgaria.
⁶ Department of Dermatology and Venereology, Medical University of Plovdiv, Plovdiv, Bulgaria.
⁷ Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Friedrichstrasse 41, 01067, Dresden, Germany.
⁸ Dermatology, University of Rome "G.Marconi", Rome, Italy.

PMID: 27832422
DOI: 10.1007/s10354-016-0525-3

Abstract

A 67-year-old woman presented with a firm plaque in the perineal region, 16 months after diagnosis of a high-grade basaloid squamous cell carcinoma of the vagina and treatment by external beam radiation therapy and vaginal cuff brachytherapy. The differential diagnosis included radiation-induced morphea, radiation dermatitis, or, possibly, radiation-induced lichen sclerosus. Biopsy findings, including special staining, confirmed the diagnosis of radiation-induced lichen sclerosus. To our knowledge, this is the first report of radiation-induced lichen sclerosus of the vulvar region.

Keywords: BCC; Dermatatis; Genital area; Lichenoid; Radiation; Surgery.

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References

1. J Eur Acad Dermatol Venereol. 2005 Jan;19(1):139-41 - PubMed
1. J Low Genit Tract Dis. 2015 Apr;19(2):135-9 - PubMed
1. Arch Dermatol. 2012 Jan;148(1):24-8 - PubMed
1. Int J Dermatol. 2007 Mar;46(3):332-3 - PubMed
1. J Obstet Gynaecol. 1997 Jan;17(1):5-12 - PubMed

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Radiation-induced lichen sclerosus of the vulva : First report in the medical literature

Affiliations

Radiation-induced lichen sclerosus of the vulva : First report in the medical literature

Authors

Affiliations

Abstract

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Full Text Sources

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Medical