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. 2017:1507:245-259.
doi: 10.1007/978-1-4939-6518-2_18.

Determination of Alternate Splicing Events Using Transcriptome Arrays

Rebecca S DeVaux  1 , Marcy Kuentzel  2 , Jason Herschkowitz  2 , Sridar V Chittur  3   4
Affiliations

Determination of Alternate Splicing Events Using Transcriptome Arrays

Rebecca S DeVaux et al. Methods Mol Biol. 2017.

Abstract

Understanding differential isoform expression is critical to mechanistically illuminate the biology underlying both normal development and disease states. High-throughput expression profiling analysis of splice variants has thus far been limited by sample requirements and an appropriate platform for quantitation and analysis. Here we describe Affymetrix GeneChip Human Transcriptome Array 2.0, which is employed for comprehensive examination of all known transcript isoforms.

Keywords: Alternative splicing; Exon splicing; Expression profiling; Gene regulation; Microarray.

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