Tackling Difficult Staphylococcus aureus Infections: Antibodies Show the Way
- PMID: 27832585
- DOI: 10.1016/j.chom.2016.10.018
Tackling Difficult Staphylococcus aureus Infections: Antibodies Show the Way
Abstract
The recent spread of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) has brought increasing concerns of heightened disease severity and persistence following invasive disease. In line with the need for new treatment paradigms, two recent reports have shown that antibody-based therapies can restrict acute S. aureus infection and persistence and improve pathological symptoms.
Keywords: IVIG; Immunoglobulin; Panton-Valentine leukocidin; Thiomab; antibiotic; intravenous immunoglobulin; necrotizing pneumonia; phagocytes; rifalogue; α-hemolysin.
Copyright © 2016 Elsevier Inc. All rights reserved.
Comment on
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Novel antibody-antibiotic conjugate eliminates intracellular S. aureus.Nature. 2015 Nov 19;527(7578):323-8. doi: 10.1038/nature16057. Epub 2015 Nov 4. Nature. 2015. PMID: 26536114
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IVIG-mediated protection against necrotizing pneumonia caused by MRSA.Sci Transl Med. 2016 Sep 21;8(357):357ra124. doi: 10.1126/scitranslmed.aag1153. Sci Transl Med. 2016. PMID: 27655850
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