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. 2017 Jan 30;23(1):109-116.
doi: 10.5056/jnm16003.

Effect of DA-9701, a Novel Prokinetic Agent, on Post-operative Ileus in Rats

Sang Pyo Lee  1 , Oh Young Lee  2 , Kang Nyeong Lee  2 , Hang Lak Lee  2 , Ho Soon Choi  2 , Byung Chul Yoon  2 , Dae Won Jun  2
Affiliations

Effect of DA-9701, a Novel Prokinetic Agent, on Post-operative Ileus in Rats

Sang Pyo Lee et al. J Neurogastroenterol Motil. .

Abstract

Background/aims: Post-operative ileus (POI) is a common complication of abdominal surgery. DA-9701, an extract of Pharbitis Semen and Corydalis Tuber, is a new prokinetic agent that also alleviates visceral pain. The aim of this study was to investigate whether DA-9701 can ameliorate POI in rats.

Methods: A total of 32 rats were divided into 4 groups: no surgery/no medication (NSNM), no surgery/medication (NSM), surgery/no medication (SNM), and surgery/medication (SM). Gastrointestinal transit (GIT), which is assessed by migration of charcoal, and cumulative stool weight were measured at 24 hours after surgery.

Results: GIT was significantly more delayed in the SNM group than in the other groups (SNM vs NSNM, P < 0.001; SNM vs NSM, P < 0.001; SNM vs SM, P = 0.005). Cumulative stool weight in that group was also lower than in the no surgery groups (SNM vs NSNM, P = 0.007; SNM vs NSM, P = 0.033), and there was no significant difference between the SM group and the no surgery groups (SM vs NSM, P = 0.703; SM vs NSNM, P = 0.347).

Conclusion: DA-9701 can ameliorate POI by reducing delayed GIT and improving defecation in a rat model of POI.

Keywords: Corydalis; DA-9701; Gastrointestinal transit; Ghrelin; Ileus.

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Figures

Figure 1
Figure 1
Schematic diagram of the experimental protocol. Pre-op, pre-operative; Post-op, post-operative; NPO, nil per os; GI, gastrointestinal.
Figure 2
Figure 2
Gastrointestinal transit (%) and cumulative stool weights (g) by group. (A) Gastrointestinal transit (GIT) was significantly delayed in the surgery/no medication (SNM) group compared with the other groups. (B) Cumulative stool weight was significantly lower in the SNM group than in the no surgery/no medication (NSNM) and no surgery/medication (NSM) groups. SM, surgery medication. The asterisk (*) indicates a statistically significant difference.
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References

    1. Doorly MG, Senagore AJ. Pathogenesis and clinical and economic consequences of postoperative ileus. Surg Clin North Am. 2012;92:259–272. viii. doi: 10.1016/j.suc.2012.01.010. - DOI - PubMed
    1. Chapelle SL, Bove GM. Visceral massage reduces postoperative ileus in a rat model. J Bodyw Mov Ther. 2013;17:83–88. doi: 10.1016/j.jbmt.2012.05.004. - DOI - PubMed
    1. Vather R, Trivedi S, Bissett I. Defining postoperative ileus: results of a systematic review and global survey. J Gastrointest Surg. 2013;17:962–972. doi: 10.1007/s11605-013-2148-y. - DOI - PubMed
    1. Choi S, Choi JJ, Jun JY, et al. Induction of pacemaker currents by DA-9701, a prokinetic agent, in interstitial cells of Cajal from murine small intestine. Mol Cells. 2009;27:307–312. doi: 10.1007/s10059-009-0039-6. - DOI - PubMed
    1. Lee TH, Choi JJ, Kim DH, et al. Gastroprokinetic effects of DA-9701, a new prokinetic agent formulated with Pharbitis Semen and Corydalis Tuber. Phytomedicine. 2008;15:836–843. doi: 10.1016/j.phymed.2008.02.019. - DOI - PubMed

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