Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2016 Nov 10;16(1):216.
doi: 10.1186/s12872-016-0392-2.

Type 2 diabetes compromises the value of non-invasively measured augmentation index in predicting the severity of coronary artery disease: a hospital-based observational study

Sijing Wu  1 , Yujie Zhou  2 , Yueping Li  1 , Yuyang Liu  1 , Dongmei Shi  1 , Xiaoli Liu  1 , Wei Liu  1 , Yi Yu  1 , Shuo Jia  1
Affiliations
Observational Study

Type 2 diabetes compromises the value of non-invasively measured augmentation index in predicting the severity of coronary artery disease: a hospital-based observational study

Sijing Wu et al. BMC Cardiovasc Disord. .

Abstract

Background: Central hemodynamic indices have been demonstrated to correlate with coronary artery disease (CAD). However, in the context of type 2 diabetes mellitus (DM), this correlation has not been fully illustrated. Therefore, this study was employed to investigate the impact of DM on the correlation between aortic augmentation index and the severity of coronary artery disease.

Methods: In this study, we analyzed 197 patients who underwent coronary angiography at Anzhen Hospital from September 2015 to January 2016. Central hemodynamics were non-invasively measured with BPro® device (Health STATS, Singapore). The severity of CAD was defined according to SYNTAX scores. Type 2 diabetes was defined according to ADA guidelines. AIx@75 was defined as AIx normalized to a heart rate of 75 bpm. Receiver operating characteristics (ROC) determined the optimal cut-off value of AIx@75 to predict moderate to severe CAD. Multivariate logistic regression analysis evaluated the correlation between central hemodynamic parameters and CAD severity.

Results: Eighty-four (42.6 %) of the studied subjects were diabetic patients. Our findings were that (1) AIx@75 was significantly correlated with SYNTAX. (ROC analyzed AUC: 0.638, 95 % CI 0.555-0.721, p < 0.05). The cut-off value of AIx@75 to predict moderate-to-severe CAD as SYNTAX score more than 22 was 71.45. (2) In non-diabetic patients, correlation analysis revealed that AIx@75, augmentation pressure and peak relative time were significantly correlated with CAD severity (p < 0.05). After adjustment, AIx@75 remained as the only independent predictor of moderate-to-severe CAD (odds ratio 1.099, 95 % CI 1.028-1.176, p < 0.05). (3) In diabetic patients, the correlation between central hemodynamic parameters and the severity of CAD did not exist.

Conclusions: Aortic augmentation index was significantly related to the severity of CAD and was an independent predictor of severe CAD. However, clinical practitioners should note that its value in DM populations was compromised.

Keywords: Augmentation index; Coronary artery disease; SYNTAX score; Type 2 diabetes mellitus.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Pressure waveform measurement. AIx = augmentation index PRT = peak relative time
Fig. 2
Fig. 2
The correlation of AIx@75 and the severity of CAD measured by SYNTAX score according to type 2 diabetes in linear regression analysis
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. McEniery CM, Cockcroft JR, Roman MJ, et al. Central blood pressure: current evidence and clinical importance. Eur Heart J. 2014;35(26):1719–25. doi: 10.1093/eurheartj/eht565. - DOI - PMC - PubMed
    1. Agabiti-Rosei E, Mancia G, O’Rourke MF, et al. Central blood pressure measurements and antihypertensive therapy: a consensus document. Hypertension. 2007;50(1):154–60. doi: 10.1161/HYPERTENSIONAHA.107.090068. - DOI - PubMed
    1. Prenner SB, Chirinos JA. Arterial stiffness in diabetes mellitus. Atherosclerosis. 2015;238(2):370–9. doi: 10.1016/j.atherosclerosis.2014.12.023. - DOI - PubMed
    1. Mizuno A, Miyauchi K, Nishizaki Y, et al. Impact of the augmentation time ratio on direct measurement of central aortic pressure in the presence of coronary artery disease. Hypertens Res. 2015;38(10):684–9. doi: 10.1038/hr.2015.53. - DOI - PubMed
    1. Cho SW, Kim BK, Kim JH, et al. Non-invasively measured aortic wave reflection and pulse pressure amplification are related to the severity of coronary artery disease. J Cardiol. 2013;62(2):131–7. doi: 10.1016/j.jjcc.2013.03.014. - DOI - PubMed

Publication types