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Case Reports
. 2017 Jan;37(1):77-80.
doi: 10.3343/alm.2017.37.1.77.

A Case of Chronic Myeloid Leukemia With Rare Variant ETV6/ABL1 Rearrangement

Soo In Choi  1 , Mi Ae Jang  1 , Woo Joon Jeong  1 , Byung Ryul Jeon  1 , Yong Wha Lee  1 , Hee Bong Shin  1 , Dae Sik Hong  2 , You Kyoung Lee  3
Affiliations
Case Reports

A Case of Chronic Myeloid Leukemia With Rare Variant ETV6/ABL1 Rearrangement

Soo In Choi et al. Ann Lab Med. 2017 Jan.
No abstract available

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Conflict of interest statement

Authors' Disclosures of Potential Conflicts of Interest: No potential conflicts of interest relevant to this article were reported.

Figures

Fig. 1
Fig. 1. Bone marrow (BM) aspiration, biopsy, karyotyping, reverse transcription (RT)-PCR, and FISH analyses of the present case. (A) BM aspiration (Wright-Giemsa stain, ×400) and (B) BM biopsy (hematoxylin & eosin stain, ×50) revealed 90% hypercellular marrow with a left-shifted neutrophilic series, an increased number of eosinophilic precursors, and small, hypolobated megakaryocytes. (C) Karyotyping showing t(9;12)(q34;p13); arrows indicate the translocated regions. (D) RT-PCR using BCR/ABL1 and ETV6/ABL1 primer pairs, revealing the 700-bp BCR/ABL1 (lane 1, arrow) and 1,141-bp ETV6/ABL1 (lane 2, arrow) fusion transcripts; left, 100-bp molecular weight marker ladder. The internal control 911-bp band is shown in lane 2. (E and F) FISH analysis using BCR/ABL1 or ETV6/RUNX1 probes, showing no abnormal signal. (G and H) FISH using the mixed BCR/ABL1 and ETV6/RUNX1 probes revealing one yellow fusion signal (ABL1, red; ETV6, green) on 9q34 analyzed in interphase (G) and metaphase (H) cells.
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