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Comment
. 2017 May 4;11(3):178-180.
doi: 10.1080/19336950.2016.1259040. Epub 2016 Nov 11.

Impaired cAMP-cGMP cross-talk during cardiac sympathetic dysautonomia

Emma N Bardsley  1   2 , Hege E Larsen  1   2 , David J Paterson  1   2
Affiliations
Comment

Impaired cAMP-cGMP cross-talk during cardiac sympathetic dysautonomia

Emma N Bardsley et al. Channels (Austin). .
No abstract available

Keywords: calcium (Ca2+); calcium channels; cellular signaling; channelopathies; ion channels; modulation of channels; molecular physiology; pharmacology; presynaptic physiology; voltage-gated ion channels.

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Figures

Figure 1.
Figure 1.
In healthy neurons, enhancing cGMP increases cAMP and PKA presumably via cGMP-dependent inhibition of PDE3. In pro-hypertensive SHR neurons, cGMP elevation reverses the ICaN phenotype, presumably by enhancing cross-talk between cGMP and cAMP signaling via activation of PDE2A. Red arrows highlight imparied activity in pro-SHR. Yellow arrows depict the downstream effects of pharmacologically enhancing cGMP.
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