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. 2016 Dec 20;7(51):85058-85062.
doi: 10.18632/oncotarget.13187.

Expressions of miR-30c and let-7a are inversely correlated with HMGA2 expression in squamous cell carcinoma of the vulva

Antonio Agostini  1   2 , Marta Brunetti  1   2 , Ben Davidson  3   4 , Claes G Trope  5 , Sverre Heim  1   2   4 , Ioannis Panagopoulos  1   2 , Francesca Micci  1   2
Affiliations

Expressions of miR-30c and let-7a are inversely correlated with HMGA2 expression in squamous cell carcinoma of the vulva

Antonio Agostini et al. Oncotarget. .

Abstract

Malignant tumors of the vulva, most of them squamous cell carcinomas, account for only 5% of cancers of the female genital tract. Though little is known about the genetic features of these tumors, the Fragile Histidine Triad (FHIT) and High Mobility Group AT-hook 2 (HMGA2) genes were found deregulated. We wanted to gain more knowledge about the expression of HMGA2-related miRNAs such as miR-30c and let-7a, and whether a correlation exists between the expression of FHIT and HMGA2, in this tumor type. An inverse correlation was found in-as-much as HMGA2 was highly expressed (mean fold change 8.8) whereas miR30c and let-7a were both downregulated (mean fold change -3.9 and -2.3, respectively). The consistent overexpression of HMGA2 found in all tumors adds to the likelihood that this gene is of importance in SCC pathogenesis. Moreover, we came to the conclusion that miRNAs may be the cause of the deregulation of HMGA2. Our results also show that SCC of the vulva presents a characteristic molecular pattern with FHIT being downregulated whereas HMGA2 is upregulated.

Keywords: FHIT; HMGA2; let-7a; miR-30c.

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Conflict of interest statement

COMPETING INTEREST

The authors have no competing interest to disclose.

Figures

Figure 1
Figure 1. Expression profile of the 10 SCC of the vulva
A. Relative normalized expression of HMGA2 and LIN28A. B. Relative normalized expression of miR-30c and let-7a.
See this image and copyright information in PMC

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