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. 2016 Dec 15:301:49-52.
doi: 10.1016/j.jneuroim.2016.10.008. Epub 2016 Nov 2.

Neuronal surface antibodies in HIV-infected patients with isolated psychosis

Vanessa Cunill  1 , Susana Arboleya  2 , Maria de Los Reyes Jiménez  3 , Antoni Campins  4 , Patricia Herbera  5 , LLuïsa Mestre  5 , Antonio Clemente  1 , Maria Inés Barceló  6 , Maria Leyes  4 , Francesca Canellas  5 , Maria Rosa Julià  1
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Neuronal surface antibodies in HIV-infected patients with isolated psychosis

Vanessa Cunill et al. J Neuroimmunol. .

Abstract

Neuronal surface antibodies (NSA) involved in autoimmune encephalitis (AE) have been related to relapses in HVS encephalitis. Their role in non-encephalitic psychosis is controversial. We previously reported an HIV-infected patient, NSA-positive, only presenting psychosis. Therefore, we determined the NSA prevalence in a prospective cohort of 22 HIV-positive patients with psychosis and we analyzed the frequency of HIV infection among NSA tested patients due to AE suspicion. We found no NSA in the prospective cohort. In the retrospective analysis, 22% of NSA-positive versus 4.6% of negative patients were HIV-positive. Wider studies are required to clarify the relationship between NSA and HIV infection.

Keywords: HIV infection; Neuronal surface antibodies; Psychosis.

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