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Review
. 2017 Feb;41(1):2-6.
doi: 10.1053/j.semperi.2016.09.012. Epub 2016 Nov 8.

Necrotizing: A historical perspective

Michael S Caplan  1 , Avroy Fanaroff  2
Affiliations
Review

Necrotizing: A historical perspective

Michael S Caplan et al. Semin Perinatol. 2017 Feb.

Abstract

Necrotizing enterocolitis is a devastating disease afflicting premature infants, though after 50 years of investigation, the pathophysiology remains elusive. This report describes the possible etiologic factors from a historical perspective, and outlines the importance of human milk, intestinal blood flow, and intestinal blood flow changes from a developmental perspective over the last 40-50 years.

Keywords: NEC; human milk; intestinal ischemia; microbiome.

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