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. 1989;51(1):73-6.
doi: 10.1159/000185246.

Effect of supernatants derived from T lymphocyte culture in minimal change nephrotic syndrome on rat kidney capillaries

K Maruyama  1 , S Tomizawa, N Shimabukuro, T Fukuda, T Johshita, T Kuroume
Affiliations

Effect of supernatants derived from T lymphocyte culture in minimal change nephrotic syndrome on rat kidney capillaries

K Maruyama et al. Nephron. 1989.

Abstract

The effect on the kidney capillaries of T lymphocyte culture supernatants from patients with minimal change nephrotic syndrome was studied by infusion into the left renal artery of rats. The supernatants of T lymphocyte cultures from nephrotic patients induced significant proteinuria and a reduction of anionic sites in the glomerular basement membrane of the kidneys in the rats. These changes were not produced in rats receiving equivalent supernatants from healthy controls.

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