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Review
. 2016 Dec;45(4):581-599.
doi: 10.1016/j.gtc.2016.07.009. Epub 2016 Oct 13.

Physiologic and Neural Controls of Eating

Timothy H Moran  1 , Ellen E Ladenheim  2
Affiliations
Review

Physiologic and Neural Controls of Eating

Timothy H Moran et al. Gastroenterol Clin North Am. 2016 Dec.

Abstract

Multiple physiologic and neural systems contribute to the controls over what and how much we eat. These systems include signaling involved in the detection and signaling of nutrient availability, signals arising from consumed nutrients that provide feedback information during a meal to induce satiation, and signals related to the rewarding properties of eating. Each of these has a separate neural representation, but important interactions among these systems are critical to the overall controls of food intake.

Keywords: Adiposity signaling; Eating; Nutrient availability; Reward processing; Satiety signals.

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Figures

Figure 1
Figure 1
Overall physiological controls of eating behavior
See this image and copyright information in PMC

References

    1. Coleman DL. Effect of parabiosis of obese and diabetes and normal mice. Diabetologia. 1973;9:194–298. - PubMed
    1. Zhang Y, et al. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372(6505):425–432. - PubMed
    1. Tartaglia LA, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell. 1995;83(7):1263–1271. - PubMed
    1. Chua SC, Jr, et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science. 1996;271(5251):994–996. - PubMed
    1. Maffei M, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med. 1995;1(11):1155–1161. - PubMed