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. 2016 Dec 1;63(suppl 4):S221-S226.
doi: 10.1093/cid/ciw528.

An Assessment of the Cocooning Strategy for Preventing Infant Pertussis-United States, 2011

Amy E Blain  1 , Melissa Lewis  1 , Emily Banerjee  2 , Kathy Kudish  3 , Juventila Liko  4 , Suzanne McGuire  5 , David Selvage  6 , James Watt  7 , Stacey W Martin  1 , Tami H Skoff  1
Affiliations

An Assessment of the Cocooning Strategy for Preventing Infant Pertussis-United States, 2011

Amy E Blain et al. Clin Infect Dis. .

Abstract

Background: Infants are at greatest risk for severe pertussis. In 2006, the Advisory Committee on Immunization Practices recommended that adolescents and adults, especially those with infant contact, receive a single dose of Tdap (tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine). To assess the effectiveness of cocooning, we conducted a case-control evaluation of infant close contacts.

Methods: Pertussis cases aged <2 months with onset between 1 January 2011 and 31 December 2011 were identified in Emerging Infections Program Network sites. For each case, we recruited 3 controls from birth certificates and interviewed identified adult close contacts (CCs) or parents of CCs aged <18 years. Pertussis vaccination was verified through medical providers and/or immunization registries.

Results: Forty-two cases were enrolled, with 154 matched controls. Around enrolled infants, 859 CCs were identified (600 adult and 259 nonadult). An average of 5.4 CCs was identified per case and 4.1 CCs per control. Five hundred fifty-four (64.5%) CCs were enrolled (371 adult and 183 non-adult CCs); 119 (32.1% of enrolled) adult CCs had received Tdap. The proportion of Tdap-vaccinated adult CCs was similar between cases and controls (P = .89). The 600 identified adult CCs comprised 172 potential cocoons; 71 (41.3%) potential cocoons had all identified adult CCs enrolled. Of these, 9 were fully vaccinated and 43.7% contained no Tdap-vaccinated adults. The proportion of fully vaccinated case (4.8%) and control (10.0%) cocoons was similar (P = .43).

Conclusions: Low Tdap coverage among adult CCs reinforces the difficulty of implementing the cocooning strategy and the importance of vaccination during pregnancy to prevent infant pertussis.

Keywords: Tdap; cocooning; pertussis.

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Conflict of interest statement

Potential conflicts of interest. All authors: no reported conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

Figures

Figure 1
Figure 1
Study enrollment flowchart. Abbreviation: CC, close contact.
Figure 2
Figure 2
Relationship of identified close contacts (CCs) to infant cases and controls.
See this image and copyright information in PMC

References

    1. Centers for Disease Control and Prevention. Nationally Notifiable Disease surveillance data. 2011.
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