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Review
. 2017 Feb 7;25(2):233-241.
doi: 10.1016/j.cmet.2016.10.009. Epub 2016 Nov 10.

Immunotherapy for Type 1 Diabetes: Why Do Current Protocols Not Halt the Underlying Disease Process?

Hubert Kolb  1 , Matthias von Herrath  2
Affiliations
Free article
Review

Immunotherapy for Type 1 Diabetes: Why Do Current Protocols Not Halt the Underlying Disease Process?

Hubert Kolb et al. Cell Metab. .
Free article

Abstract

T cell-directed immunosuppression only transiently delays the loss of β cell function in recent-onset type 1 diabetes. We argue here that the underlying disease process is carried by innate immune reactivity. Inducing a non-polarized functional state of local innate immunity will support regulatory T cell development and β cell proliferation.

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