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. 1989 Feb;86(4):1168-72.
doi: 10.1073/pnas.86.4.1168.

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas

W Y Langdon  1 , J W Hartley, S P Klinken, S K Ruscetti, H C Morse 3rd
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v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas

W Y Langdon et al. Proc Natl Acad Sci U S A. 1989 Feb.

Abstract

Cas NS-1 is an acutely transforming murine retrovirus that induces pre-B and pro-B cell lymphomas. Molecular cloning showed it was generated from the ecotropic Cas-Br-M virus by sequential recombinations with endogenous retroviral sequences and a cellular oncogene. The oncogene sequence shows no homology with known oncogenes but some similarity to the yeast transcriptional activator GCN4. A 100-kDa gag-cbl fusion protein, with no detectable kinase activity, is responsible for the cellular transformation. The cellular homologue of v-cbl, present in mouse and human DNA, is expressed in a range of hemopoietic lineages.

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References

    1. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Feb;74(2):789-92 - PubMed
    1. J Virol. 1979 Jun;30(3):787-98 - PubMed
    1. J Virol. 1979 Sep;31(3):752-60 - PubMed
    1. Nature. 1980 Feb 28;283(5750):826-31 - PubMed

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