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Review
. 2017 Mar 2:231:103-107.
doi: 10.1016/j.virusres.2016.11.010. Epub 2016 Nov 10.

Papillomavirus assembly: An overview and perspectives

Carla Cerqueira  1 , John T Schiller  2
Affiliations
Review

Papillomavirus assembly: An overview and perspectives

Carla Cerqueira et al. Virus Res. .

Abstract

Papillomavirus life cycle is tightly coupled to epithelial cell differentiation, which has hindered the investigation of many aspects of papillomavirus biology, including virion assembly. The development of in vitro production methods of papillomavirus pseudoviruses, and the production of "native" virus in raft cultures have facilitated the study of some aspects of the assembly process. In this paper we review the current knowledge of papillomavirus assembly, directions for future research, and the implications of these studies on new therapeutic interventions.

Keywords: Papillomavirus; Pseudovirus; Virion assembly.

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