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. 2016;18(13):3718-3721.
doi: 10.1039/C6GC00910G. Epub 2016 May 19.

An Efficient Passerini Tetrazole Reaction (PT-3CR)

Ajay L Chandgude  1 , Alexander Dömling  1
Affiliations

An Efficient Passerini Tetrazole Reaction (PT-3CR)

Ajay L Chandgude et al. Green Chem. 2016.

Abstract

A sonication accelerated, catalyst free, simple, high yielding and efficient method for the Passerini-type three component reaction (PT-3CR) has been developed. It comprises reaction of an aldehyde/ketone, a isocyanide and a TMS-azide in methanol:water (1:1) as the solvent system. Use of sonication not only accelerated the rate of the reaction but also provided up to quantitative yields. This reaction is applicable to a broad scope of aldehyde/ketone and isocyanides.

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Figures

Fig 1
Fig 1
Some bio-active agents/drugs containing the tetrazole moiety.
Scheme 1
Scheme 1
Synthesis of fused tetrazole.
See this image and copyright information in PMC

References

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