Microglia communication: Parallels between aging and Alzheimer's disease

Abstract

Aging alters the functional integrity of the adult brain, driving cognitive impairments and susceptibility to neurodegenerative disorders in healthy individuals. In fact, aging remains the most dominant risk factor for Alzheimer's disease (AD). Recent findings have expanded our understanding of microglia function in the normal aging and AD brain, provoking an appreciation for microglia involvement in remodeling neuronal connections and maintaining brain integrity. This homeostatic function of microglia is achieved in part through the ability of microglia to interact extensively with and rapidly respond to changes in the brain microenvironment to enable adequate phenotypic transformations. Here, we discuss pro-inflammatory drivers of microglia transformation in aging and AD by focusing on the immune-modulatory functions of secreted factors, such as cytokines, complement factors and extracellular vesicles. We highlight the involvement of these secreted factors in aging and AD-associated cellular changes in microglia immune activation, surveillance function, and phagocytosis. Finally, we discuss how pro-inflammatory phenotypic changes associated with altered immune communication could both facilitate and exacerbate impairments in synaptic plasticity and cognitive function observed in the aged and AD brain.

Keywords: aging; alzheimer's disease; microglia; neuroinflammation.

Figure 1

Aging alters microglia communication driving age‐ and Alzheimer's disease (AD)‐related functional impairments in the brain. Young microglia (gray) adopt a pro‐inflammatory phenotype during aging (orange) and AD (red). These cellular changes alter microglia communication through cytokines, complements and extracellular vesicles (EV), promoting increased inflammation, decreased phagocytosis and decreased motility. Functional consequences of these aging‐ and AD‐related changes in microglia communication result in neuronal impairments in synaptic plasticity and cognition.