Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2016 Dec 1;126(12):4396-4398.
doi: 10.1172/JCI91300. Epub 2016 Nov 14.

Prevention of preeclampsia

Chad A Grotegut
Comment

Prevention of preeclampsia

Chad A Grotegut. J Clin Invest. .

Abstract

Preeclampsia is a common complication of pregnancy that is associated with an increased risk of maternal and neonatal morbidity and mortality. Currently, delivery is the only cure for preeclampsia; therefore, effective prevention and treatment options for this condition are sorely needed. In the current issue of the JCI, Mirzakhani et al. report the findings of the Vitamin D Antenatal Asthma Reduction Trial (VDAART), a well-conducted large, randomized, double-blind, placebo-controlled trial of vitamin D supplementation for the prevention of preeclampsia. Though vitamin D supplementation had no effect on the risk of preeclampsia, reduced maternal serum vitamin D levels did correlate with preeclampsia risk. Mirzakhani and colleagues identified a number of gene pathways that are differentially regulated among women with low serum vitamin D levels who develop preeclampsia. These results indicate that further research on the role of vitamin D in preeclampsia is warranted.

PubMed Disclaimer

Conflict of interest statement

The author has declared that no conflict of interest exists.

Comment on

  • Early pregnancy vitamin D status and risk of preeclampsia.
    Mirzakhani H, Litonjua AA, McElrath TF, O'Connor G, Lee-Parritz A, Iverson R, Macones G, Strunk RC, Bacharier LB, Zeiger R, Hollis BW, Handy DE, Sharma A, Laranjo N, Carey V, Qiu W, Santolini M, Liu S, Chhabra D, Enquobahrie DA, Williams MA, Loscalzo J, Weiss ST. Mirzakhani H, et al. J Clin Invest. 2016 Dec 1;126(12):4702-4715. doi: 10.1172/JCI89031. Epub 2016 Nov 14. J Clin Invest. 2016. PMID: 27841759 Free PMC article. Clinical Trial.

References

    1. HCUP Statistical Briefs Chronological. Healthcare Cost and Utilization Project (HCUP). Agency for Healthcare Research and Quality, Rockville, Maryland USA. HCUP Web site. www.hcup-us.ahrq.gov/reports/statbriefs/statbriefs.jsp Accessed October 19, 2016.
    1. American College of Obstetricians Gynecologists Task Force on Hypertension Pregnancy. Hypertension In Pregnancy. Washington, DC, USA: ACOG; 2013. - PubMed
    1. Roberts JM, Hubel CA. The two stage model of preeclampsia: variations on the theme. Placenta. 2009;30(Suppl A):S32–S37. - PMC - PubMed
    1. Moffett-King A. Natural killer cells and pregnancy. Nat Rev Immunol. 2002;2(9):656–663. doi: 10.1038/nri886. - DOI - PubMed
    1. Levine RJ, et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med. 2004;350(7):672–683. doi: 10.1056/NEJMoa031884. - DOI - PubMed