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Comparative Study
. 2017 Jan;107(1):110-118.
doi: 10.1016/j.fertnstert.2016.10.002. Epub 2016 Nov 11.

Cryopreserved oocyte versus fresh oocyte assisted reproductive technology cycles, United States, 2013

Sara Crawford  1 , Sheree L Boulet  2 , Jennifer F Kawwass  3 , Denise J Jamieson  2 , Dmitry M Kissin  2
Affiliations
Comparative Study

Cryopreserved oocyte versus fresh oocyte assisted reproductive technology cycles, United States, 2013

Sara Crawford et al. Fertil Steril. 2017 Jan.

Abstract

Objective: To compare characteristics, explore predictors, and compare assisted reproductive technology (ART) cycle, transfer, and pregnancy outcomes of autologous and donor cryopreserved oocyte cycles with fresh oocyte cycles.

Design: Retrospective cohort study from the National ART Surveillance System.

Setting: Fertility treatment centers.

Patient(s): Fresh embryo cycles initiated in 2013 utilizing embryos created with fresh and cryopreserved, autologous and donor oocytes.

Intervention(s): Cryopreservation of oocytes versus fresh.

Main outcomes measure(s): Cancellation, implantation, pregnancy, miscarriage, and live birth rates per cycle, transfer, and/or pregnancy.

Result(s): There was no evidence of differences in cancellation, implantation, pregnancy, miscarriage, or live birth rates between autologous fresh and cryopreserved oocyte cycles. Donor cryopreserved oocyte cycles had a decreased risk of cancellation before transfer (adjusted risk ratio [aRR] 0.74, 95% confidence interval [CI] 0.57-0.96) as well as decreased likelihood of pregnancy (aRR 0.88, 95% CI 0.81-0.95) and live birth (aRR 0.87, 95% CI 0.80-0.95); however, there was no evidence of differences in implantation, pregnancy, or live birth rates when cycles were restricted to those proceeding to transfer. Donor cryopreserved oocyte cycles proceeding to pregnancy had a decreased risk of miscarriage (aRR 0.75, 95% CI 0.58-0.97) and higher live birth rate (aRR 1.05, 95% CI 1.01-1.09) with the transfer of one embryo, but higher miscarriage rate (aRR 1.28, 95% CI 1.07-1.54) and lower live birth rate (aRR 0.95, 95% CI 0.92-0.99) with the transfer of two or more.

Conclusion(s): There was no evidence of differences in ART outcomes between autologous fresh and cryopreserved oocyte cycles. There was evidence of differences in per-cycle and per-pregnancy outcomes between donor cryopreserved and fresh oocyte cycles, but not in per-transfer outcomes.

Keywords: Assisted reproductive technology (ART); egg freezing; in vitro fertilization (IVF); vitrification.

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References

    1. Practice Committee of the American Society for Reproductive Medicine, Society for Assisted Reproductive Technology. Mature oocyte cryopreservation: a guideline. Fertil Steril. 2013;99:37–43. - PubMed
    1. Barclay E. [Accessed December 16, 2015];More women are freezing their eggs, but will they ever use them? Shots: health news from NPR. Available at: www.npr.org/sections/health-shots/2015/11/24/456671203/more-women-are-fr....
    1. Devine K, Mumford SL, Goldman KN, Hodes-Wertz B, Druckenmiller S, Propst AM, et al. Baby budgeting: oocyte cryopreservation in women delaying reproduction can reduce cost per live birth. Fertil Steril. 2015;103:1446–53. - PMC - PubMed
    1. Mesen TB, Mersereau JE, Kane JB, Steiner AZ. Optimal timing for elective egg freezing. Fertil Steril. 2015;103:1551–6. - PMC - PubMed
    1. Centers for Disease Control and Prevention, American Society for Reproductive Medicine, Society for Assisted Reproductive Technology. 2013 assisted reproductive technology fertility clinic success rates report. Atlanta, GA: US Department of Health and Human Services; 2015.

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